Fig. 2.

Pathological changes of pancreata in cyclooxygenase (COX)-2/Cre mice. A: pancreatic COX-2 expression led to an increased pancreas-to-body weight ratio (*P < 0.01, #P < 0.05). Values are means ± SE. Ela-CreERT (Cre) mice were used as control. B: expression level of COX-2 at different ages of mice. C: hematoxylin and eosin (H&E) staining shows the pathological changes caused by COX-2 expression in the pancreas. Cystic ductal lesions, tubular complex (TC), acinar-to-ductal metaplasia (ADM), and low-grade pre-neoplastic pancreatic intraepithelial neoplasms (PanINs) were observed.