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Inflammation and fibrogenesis in cyclooxygenase (COX)-2/Cre mice. A: immunohistochemical stain for amylase showed a progressive loss of acinar cells in COX-2 expressing pancreata. B: CD11b staining showed dramatic inflammatory cell infiltration in COX-2 mice. C: Sirius red staining indicated progressive fibrogenesis in COX-2 expressing mice. D: Alcian blue staining revealed acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasia in COX-2 expressing mice.
