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Upregulation of key cytokines and profibrogenic factors in cyclooxygenase (COX)-2/Cre mice. Interleukin (IL)-1β (A), tumor necrosis factor (TNF)-α (B), fibronectin (C), and transforming growth factor (TGF)-β (D) were significantly increased in the pancreata of COX-2-expressing mice (30 wk) (*P < 0.05). Values are means ± SE.
