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Activation of phosphorylated signal transducers and activators (p-STAT3), phosphorylated extracellular signal-regulated kinase (p-ERK), α-smooth muscle actin (α-SMA), and Ki-67 signaling pathways in cyclooxygenase (COX)-2 mice. Immunohistochemical staining results showed the expression of p-STAT3 (A), p-ERK (B), α-SMA (C), and Ki-67 (D) in the pancreatic tissues of mice expressing COX-2 at different time points (20, 50, and 80 wk).
