Table 1.

Pathological scoring of the pancreatic tissues in COX-2/Cre mice after different time periods

	Weeks
Pathology	10/20	30	80	P Values
Acinar atrophy	0	0.80 ± 0.45	2.60 ± 0.55	0.0001
Inflammatory cell infiltration	0	1.00 ± 0.71	1.60 ± 0.55	0.172
Edema	0	0.40 ± 0.55	1.20 ± 0.84	0.111
Fibrosis	0	0.80 ± 0.45	3.00 ± 0.00	<0.0001
Tubular complex	0	1.40 ± 0.55	2.80 ± 0.45	0.02
Total score	0	4.40 ± 1.95	11.2 ± 0.84	<0.0001

Values are means ± SE; n = 5 mice. Histological scoring of acinar atrophy, inflammatory cell infiltration, edema, fibrosis, and tubular complex in cyclooxygenase (COX)-2/Cre mice. Lesion sizes in each microscopic field were evaluated as follows: 0 = absent; 1 = a lesion slightly shown in lobule or intralobular region (less than one-half); 2 = a lesion widely shown in lobule or intralobular region (more than one-half); 3 = a lesion shown across lobule and intralobular region or with destruction of lobular architecture. Significant differences (P < 0.05) between 80 wk and 30 wk indicated the progression of chronic pancreatitis.