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Antifibrotic compounds attenuated the fibrotic phenotype in rat fibrotic precision-cut liver tissue slices (PCLSs) after 48 h of incubation. SB525334, nintedanib, and sorafenib suppressed fibrotic gene expression in rat fibrotic PCLSs (A) and procollagen I secretion in the conditioned medium (B). Data are means ± SE; n = 3 rats for both sham and bile duct ligation (BDL); n = 8–10 liver slices for each condition. *P < 0.05, **P < 0.01, ***P < 0.001.
