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. 2018 Oct 25;316(1):G132–G143. doi: 10.1152/ajpgi.00131.2018

Fig. 2.

Fig. 2.

Alosetron and granisetron increase the visceromotor response (VMR) to colorectal balloon distention (CRD) in serotonin transporter-knockout (SERT-KO) but not wild-type (WT) female rats. A: VMR recorded at the indicated pressure before (control; n = 5) and after saline treatment in WT (n = 5; left) and SERT-KO (n = 5) rats (right). B: alosetron (0.1 mg/kg sc) increased the VMR in female SERT-KO (n = 6; right) but not WT (n = 6; left) rats. C: granisetron (0.1 mg/kg sc) also increased the VMR in SERT-KO (n = 6) but not WT (n = 6) female rats. *Significantly different from control (P < 0.05). Data are means ± SE.