Table 3.
GO analysis of differentially expressed genes associated with IIA stage colon cancer.
| regulation | Category | Term | Count | % | P-Value | Fold Enrichment | FDR |
|---|---|---|---|---|---|---|---|
| up | GOTERM_BP_FAT | GO:0010646~regulation of cell communication | 234 | 24.92013 | 2.36E-12 | 1.526744778 | 4.63E-09 |
| up | GOTERM_BP_FAT | GO:0023051~regulation of signaling | 236 | 25.13312 | 4.03E-12 | 1.514715803 | 7.91E-09 |
| up | GOTERM_BP_FAT | GO:0007399~nervous system development | 180 | 19.16933 | 8.89E-12 | 1.63444496 | 1.75E-08 |
| up | GOTERM_BP_FAT | GO:0010604~positive regulation of macromolecule metabolic process | 220 | 23.42918 | 2.72E-11 | 1.517826065 | 5.34E-08 |
| up | GOTERM_BP_FAT | GO:0007167~enzyme linked receptor protein signaling pathway | 98 | 10.43663 | 2.73E-11 | 2.024115217 | 5.37E-08 |
| up | GOTERM_MF_FAT | GO:0005057~receptor signaling protein activity | 27 | 2.875399 | 2.69E-08 | 3.580476019 | 4.39E-05 |
| up | GOTERM_MF_FAT | GO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 41 | 4.366347 | 1.00E-06 | 2.33015106 | 0.001631 |
| up | GOTERM_MF_FAT | GO:0019899~enzyme binding | 136 | 14.48349 | 1.81E-06 | 1.481913682 | 0.002953 |
| up | GOTERM_MF_FAT | GO:0008092~cytoskeletal protein binding | 75 | 7.98722 | 3.96E-06 | 1.728165139 | 0.006455 |
| up | GOTERM_MF_FAT | GO:0019904~protein domain specific binding | 59 | 6.28328 | 4.69E-06 | 1.873173393 | 0.00764 |
| up | GOTERM_CC_FAT | GO:0030054~cell junction | 123 | 13.09904 | 2.20E-09 | 1.711673403 | 3.35E-06 |
| up | GOTERM_CC_FAT | GO:0031252~cell leading edge | 44 | 4.685836 | 2.05E-07 | 2.378506707 | 3.12E-04 |
| up | GOTERM_CC_FAT | GO:0005912~adherens junction | 69 | 7.348243 | 3.11E-07 | 1.907961809 | 4.74E-04 |
| up | GOTERM_CC_FAT | GO:0070161~anchoring junction | 69 | 7.348243 | 7.57E-07 | 1.862342469 | 0.001153 |
| down | GOTERM_BP_FAT | GO:0007399~nervous system development | 546 | 18.8601 | 3.19E-36 | 1.619387 | 6.50E-33 |
| down | GOTERM_BP_FAT | GO:0006357~regulation of transcription from RNA polymerase II promoter | 468 | 16.1658 | 4.34E-32 | 1.64145 | 8.83E-29 |
| down | GOTERM_BP_FAT | GO:0051254~positive regulation of RNA metabolic process | 375 | 12.95337 | 7.66E-29 | 1.705661 | 1.56E-25 |
| down | GOTERM_BP_FAT | GO:0006366~transcription from RNA polymerase II promoter | 453 | 15.64767 | 1.98E-28 | 1.601934 | 4.03E-25 |
| down | GOTERM_BP_FAT | GO:1903508~positive regulation of nucleic acid-templated transcription | 360 | 12.43523 | 2.90E-28 | 1.717546 | 5.91E-25 |
| down | GOTERM_MF_FAT | GO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding | 188 | 6.493955 | 3.54E-17 | 1.799249 | 6.12E-14 |
| down | GOTERM_MF_FAT | GO:0001067~regulatory region nucleic acid binding | 225 | 7.772021 | 7.28E-16 | 1.663386 | 1.34E-12 |
| down | GOTERM_MF_FAT | GO:0000975~regulatory region DNA binding | 224 | 7.737478 | 1.35E-15 | 1.657928 | 2.31E-12 |
| down | GOTERM_MF_FAT | GO:0044212~transcription regulatory region DNA binding | 223 | 7.702936 | 1.78E-15 | 1.656331 | 3.08E-12 |
| down | GOTERM_MF_FAT | GO:0043565~sequence-specific DNA binding | 267 | 9.222798 | 3.59E-15 | 1.566314 | 6.15E-12 |
| down | GOTERM_CC_FAT | GO:0005654~nucleoplasm | 632 | 21.83074 | 2.75E-18 | 1.331786 | 4.42E-15 |
| down | GOTERM_CC_FAT | GO:0043005~neuron projection | 233 | 8.048359 | 5.31E-12 | 1.522783 | 8.54E-09 |
| down | GOTERM_CC_FAT | GO:0097458~neuron part | 297 | 10.25907 | 8.60E-11 | 1.406649 | 1.38E-07 |
| down | GOTERM_CC_FAT | GO:0098644~complex of collagen trimers | 18 | 0.621762 | 9.04E-10 | 4.940876 | 1.45E-06 |