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Simvastatin decreases the content and protein expression of inflammatory cytokines in diabetic heart tissue. Simvastatin decreases the contents of IL-6 and TNF-α in serum of diabetic rats (A, B) and downregulates the protein expression of ICAM-1, IL-6, TNF-α and VCAM-1 in heart tissue (C–F). Data are expressed as the mean ±SD. n=10 for A and B, n=4 for C–F. * p<0.05 was considered statistically significant.
