Fig. 1.

Survival rate and body weights of mice exposed to LPS early in life. Newborn mice treated intraperitoneally with LPS at doses of 3 (L3), 6 (L6), or 10 (L10) mg/kg or vehicle (PBS) on postnatal days 3–5 were monitored for survival and weight gain over the first 14 days of life. A: percent survival of PBS- and LPS-treated mice (n = 20–31/group). The data shown are representative of four independent experiments. Log-rank (Mantel-Cox) testing showed significant differences in the percent survival between mice treated with PBS and 6 or 10 mg/kg of LPS. B: body weight (in g) of PBS- and LPS-treated mice. The data shown are representative of four independent experiments. Values are presented as means ± SD (n = 20–31/group). Two-way ANOVA showed an effect of LPS and age and an interaction between them for the dependent variable, body weight. Significant differences between PBS- and LPS-treated animals are indicated by **P < 0.01 and *P < 0.05.