Fig. 3.

Lung proteomics of mice exposed to LPS early in life. The lung tissues of 4-day-old mice were collected 24 h after treatment with the vehicle control (PBS; n = 4) or one dose of LPS (10 mg/kg; n = 4) and analyzed in a reverse-phase protein array assay. Heatmap of unsupervised hierarchical clustering of LPS-treated mice inclusive of significantly different (P < 0.05) protein expression data (A). Significantly downregulated proteins (B) and significantly upregulated proteins (C) in the lungs of LPS-treated mice. Gene Ontology analysis of significant downregulated (D) and upregulated (E) biological processes in the lungs of LPS-treated mice. FGFR, fibroblast growth factor receptor; STAT, signal transducer and activator of transcription.