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. Author manuscript; available in PMC: 2019 Jun 6.
Published in final edited form as: Neuron. 2018 May 10;98(5):992–1004.e4. doi: 10.1016/j.neuron.2018.04.030

Figure 3: Optogenetic activation of serotonergic fibers in CA1 elicits a fast transient hyperpolarization of CA1 pyramidal neurons.

Figure 3:

(a) Experimental configuration and circuit schematic. (a-b) 2 or 20 Hz optogenetic stimulation of ePet1-cre+/−;Ai32+/− (ChR2+/−) hippocampal slices induces a rapid hyperpolarization of CA1 pyramidal neurons. A cocktail of 5-HT receptor antagonists (GR113808, 100 nM; Odansetron, 10 nM; WAY100,635, 100 nM) blocked this hyperpolarization. Vm traces are taken from experiments representative of the population average. T-test based significant differences from baseline and between groups are indicated. *: p < 0.05, ***: p < 0.001.