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. 2019 Feb 5;38(2):176–183. doi: 10.1089/dna.2018.4462

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© Guodong Ma et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 1. — lncRNA LINC00460 presents the highly expressed levels in the NSCLC tissue and unfavorable prognosis. (A) RT-PCR analysis revealed the levels of LINC00460 in clinically enrolled NSCLC tissue. (B) RT-PCR analysis revealed the lncRNA LINC00460 expression in the NSCLC patients who were diagnosed with gefitinib resistance, or sensitive to the gefitinib chemotherapy. (C) LINC00460 expression in the NSCLC cell lines compared with normal cells. (D) LINC00460 expression in gefitinib-resistant cells (A549/GR, gefitinib resistant) and cultured parental A549 cells. (E) Survival analysis revealed the survival rate of NSCLC patients who were accompanied by high LINC00460 expression or lower individuals. Data are expressed as mean ± SD. **p < 0.01 represents statistical difference. lncRNA, long noncoding RNA; NSCLC, nonsmall cell lung cancer; RT-PCR, real-time polymerase chain reaction.