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. 2019 Feb 5;38(2):176–183. doi: 10.1089/dna.2018.4462

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© Guodong Ma et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — EGFR enhances the role of LINC00460 in the gefitinib chemotherapy resistance of NSCLC cells. (A, B) The correlation of EGFR with LINC00460 and miR-769-5p was analyzed using Pearson's correlation analysis. (C) Western blots showed the EGFR protein expression in control cells (A549) and gefitinib-resistant NSCLC cells (A549/GR). (D, E) EGFR protein expression in A549/GR cells transfected with si-LINC00460 and miR-769-5p mimics. (F) Chemotherapy-sensitive test with CCK-8 revealed the IC50 value of A549/GR cells cotransfected with the siRNA or/and EGFR overexpression plasmids. (G) Transwell invasion assay revealed the invasion of NSCLC cells. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01 represents statistical difference.