Figure 4.

Treatment had no effect on subchondral bone changes in the mild-to-moderate posttraumatic OA model. (A) Representative images of tibial subchondral bone from the zone of articulation for both a sham and surgical animal. Scale bar represents 0.25 mm. (B) A significant elevation in bone volume/total volume (BV/TV) was seen at both 2.5- and 3.5-months post-surgery in all groups except sham. (C) Consistent with BV/TV, trabecular spacing (depicted as volume of trabecular space) was significantly decreased in all experimental groups compared to sham controls at both 2.5- and 3.5-months post-surgery indicating bone sclerosis. Data are represented by min-to-max box and whisker plots. n = 4 (2.5 months; all groups) and 6 (3.5 months; all groups). *p < 0.05 ANOVA.