Figure 3.

Mouse activity comparisons pre- and post-treadmill exercise. (A) A significant difference in pre-exercise resting time is observed between WT (dotted line) and TazKD (dashed line) (p ≤ 0.01) but no significant difference is observed between the two post-exercise (B). Average resting times are decreased in all treatment cohorts as compared to untreated TazKD controls pre- and post-exercise except for Taz-TAZ treated as adults (pre) and neonates (post). A significant difference in slow movement time is observed between WT and TazKD mice both pre-exercise (C) and post-exercise (D) (p ≤ 0.001) and this is decreased in all treatment cohorts except CMV-TAZ treated as adults with differences between promoters indicated. (E, F) A significant decrease in fast movement time is observed in TazKD mice as compared with WT mice both pre- and post-exercise (p ≤ 0.01) and this is significantly increased in all treatment cohorts. A significant decrease in average distance traveled is observed in TazKD mice as compared to WT controls both pre-and post-exercise (p ≤ 0.01) and this is also increased in all treatment cohorts (G, H). Data are represented as Mean ± SEM (n ≥ 5). Significant differences between promoters for each treatment age are indicated by lines above bars and significant improvement between each individual sample and untreated TazKD controls is indicated at the bottom of bars (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001).