Figure 4.

Cardiac function and heart weight characterizations. A significant decrease in FS% (A) and EF% (B) is observed in TazKD (dashed line) as compared to WT (dotted line) mice (p ≤ 0.001). These measurements were both increased in all treated cohorts. (C) TazKD mice also display a significantly increased heart weight/body weight ratio as compared to WT controls (p ≤ 0.001) that is decreased in all treated cohorts except CMV-TAZ and Taz-TAZ mice treated as neonates. Data are represented as mean ± SEM (n = 8). Significant differences between promoters for each treatment age are indicated by lines above bars and significant improvement between each individual sample and untreated TazKD controls is indicated by * at the bottom of bars (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001). FS, fractional shortening; EF, ejection fraction.