Figure 6.

Mitochondrial structure evaluations. (A–H) Representative EM images of cardiac mitochondria from WT, TazKD, and all AAV treatment cohorts. Fifteen images from each of four samples were evaluated per group. (I–K) Quantitative evaluations of images (A–H) revealed significant differences between TazKD (dashed line) and WT (dotted line) mitochondrial area, number, and width (***p ≤ 0.001). (I) Improved mitochondrial area was observed in all treatment cohorts. (J) Improved number of mitochondria per field was observed in every cohort except for Des-TAZ mice treated as neonates. (K) Improved mitochondrial width was observed in every cohort. Data are represented as mean ± SEM. Significant differences between promoters for each treatment age are indicated by lines above bars and significant improvement between each individual sample and untreated TazKD controls is indicated at the bottom of bars (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001).