Figure 2.
Imbalanced expression of matriptase relative to HAIs is worsening in haematological cancer cells versus carcinoma cells. (A) The relative mRNA expression levels of matriptase (st14), HAI-1 (spint1), and HAI-2 (spint2) in the whole cancer cell lines from CCLE were comprehensively retrieved, presented, and compared using the UCSC Xena Platform41. The amount of matriptase mRNA expression in each cell line was obtained and ranked from high to low. The mRNA expression levels of HAI-1 and HAI-2 were arranged in the order of the amount of matriptase expression. The size of each block represents 50 cell lines. The RNA-seq reading count is proportional to the depth of the red, as shown below each lane. (B) Matriptase, HAI-1, and HAI-2 mRNA expression levels (Log RPKM) of eight major blood cancer subclasses were retrieved from the histological type of “haematopoietic and lymphoid tissue classification” in the CCLE database. Horizontal dashed lines are used to distinguish the threshold for mRNA expression levels identified as proteins that may be expressed in cell lines. (C) The logarithm of HAI-1:matriptase or HAI-2:matriptase expression was calculated from the epithelial origin and haematological origin retrieved from CCLE database, respectively. The horizontal dotted line represents the ratio of HAIs:matriptase was 1:1.