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. 2019 Feb 19;34(1):692–702. doi: 10.1080/14756366.2019.1577831

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — HAI-2 can function as matriptase enzymatic inhibitor in neoplastic B-cells. One million Ramos (A) and Namalwa cells (B) were transiently exposed to PBS as non-activation control (lanes 1 and 2) or a pH 6.0 buffer to induce matriptase zymogen activation (lanes 3 and 4). The cell lysates (lanes 1 and 3, indicated by C) and the conditioned buffer (lanes 2 and 4, indicated by S) were prepared to give identical final volumes. Equal volumes of these samples were analysed by western blot for matriptase and the highly glycosylated (High gly.) and lightly glycosylated (Light gly.) HAI-2 species. MTP-HAI-2-X stands for matriptase-HAI-2-protease X complexes, MTP-HAI-2 for matriptase-HAI-2 complex, MTP for matriptase. The immunoblot data presented are representative examples of at least three independent experiments.