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c-Met/PI3K/Akt signaling in ROS generation, lamellipodia formation, and cell motility. c-Met/PI3K/Akt signaling cascade modulates actin and cortactin redistribution to cell periphery, translocation of p47phox and Rac1, components of NADPH oxidase (NOX) 2, resulting reactive oxygen species (ROS) generation at cell periphery, which is critical for lamellipodia formation. Phosphorylation of paxillin by HGF or S1P also regulates NOX2-generated ROS and lamellipodia formation.
