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. 2018 Nov 21;121(1):96–104. doi: 10.1152/jn.00613.2018

Fig. 1.

Fig. 1.

Expression of diffuse noxious inhibitory controls (DNIC) in early- and late-phase monoiodoacetate (MIA) animals and sham controls. A: a conditioning noxious ear pinch produced a significant reduction in mechanically evoked neuronal firing in ipsilateral wide dynamic range (WDR) neurons in early-phase MIA animals (n = 19). B: in late-phase MIA animals, a conditioning noxious ear pinch no longer produces a reduction in mechanically evoked neuronal firing in ipsilateral WDR neurons (n = 42). C: a conditioning noxious ear pinch produced a significant reduction in mechanically evoked neuronal firing in ipsilateral WDR neurons in sham controls (n = 27). D–F: representative tracts from ipsilateral WDR neurons in early-phase MIA (D), late-phase MIA (E), and sham animals (F) showing 3 baseline preconditioned responses and a DNIC response with a concurrent noxious ear pinch. **P < 0.01; ***P < 0.001; two-way ANOVA with Bonferroni correction.