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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Jan 8;1861(4):760–767. doi: 10.1016/j.bbamem.2019.01.001

Figure 6. Ionic lock interactions with and without cholesterol at the CCM.

Figure 6.

The left panel shows a typical state of the ionic lock when cholesterol is bound at the CCM, in which T41 (1/2 turn of helix removed from the Y43 of the CCM) does not participate in the ionic lock interaction network. The right panel shows the tight interaction between the residues of the ionic lock, including T41 from helix 2 and R102 and E228 from the conserved ionic lock motif.