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. 2019 Feb 1;10(10):1085–1101. doi: 10.18632/oncotarget.26628

Figure 2. Andrographolide decreased PC3 cell migration and invasion.

Figure 2

(A) Confluent monolayer of PC3 cells was wounded by scratching with a pipette tip and were incubated with or without Andrographolide for 0, 12 and 24 hours. Photomicrographs were taken of PC3 treated with Andrographolide at 0, 12 and 24 hours. (B) Quantification of percentage of migration showed that Andrographolide significantly reduced cell migration at 12 and 24 hours when compared to control. (C) To evaluate Andrographolide effect in invasion, PC3 cells were incubated for 12 hours and 24 hours with or without Andrographolide. Invasion was evaluated using the boyden chamber method. Photomicrographs were taken of PC3 treated with Andrographolide for 12 hours and 24 hours. (D) Andrographolide significantly reduced cell invasion. Experiments were made in triplicate. Statistical analysis was performed using t-test. Mean + SEM (*P < 0.05).