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. 2019 Feb 1;10(10):1085–1101. doi: 10.18632/oncotarget.26628

Figure 4. Andrographolide decreased tumor growth, MMP11 expression and proliferation.

Figure 4

Tumor growth was evaluated using an orthotopic model. Anterior prostate lobes were injected with 22RV1 cells. Tumors were allowed to develop for 4 weeks and Andrographolide was administered three times per week with intraperitoneal injections. The tumor volume was determined with caliper measurements. (A) Representative images of tumors show differences in size. (B) Tumor volume quantification. Ncontrol = 6, NAndrographolide = 6. Mean + SEM (*P < 0.05). (C) Representative images of vehicle and Andrographolide 10 mg/kg tumors for hematoxylin and eosin (H & E) (D) We measured the expression of MMP11 on tumors treated with Andrographolide 10 mg/kg and control. (E) The expression of pH3 and Ki-67 was evaluated in 22RV1 tumor tissue. Vehicle at the left; Andrographolide 10 mg/kg at the right. Andrographolide 10 mg/kg reduced cell proliferation in vivo. Statistical analysis was performed using t-test. Mean + SEM (*P < 0.05).