Figure 5. DST treatment restores E-cadherin levels in drug-sensitive BxPC3 xenografts.

Nude mice were inoculated with BxPC3, PANC1, or MiaPaCa-2 cells (2×10⁶) and treated with vehicle or DST (25 mg/kg) for 14 days before sacrifice. Histological analysis was performed for E-cadherin and pSrc levels in response to treatment in drug-sensitive BxPC3 (A) and drug-resistant PANC1 and MiaPaCa-2 (B) cell xenografts. Measurements were performed in triplicate and reported as a percentage positive staining of total area. (scale bar = 50μm) ^**p<0.01, ^***p<0.001, ^****p<0.0001, ^ns not significant.