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. 2019 Feb 1;10(10):1056–1069. doi: 10.18632/oncotarget.26621

Figure 6. Proposed mechanism of action for DST in drug-sensitive and resistant PDAC cell lines.

Figure 6

Inhibition of Src kinase in drug-sensitive PDAC cells results in reduced transcription of the pro-EMT transcription factor, Slug. This allows for enhanced E-cadherin transcription and stabilization of the E-cadherin/β-catenin membrane complex. In DST-resistant PDAC cell lines, DST treatment results in a reduction in levels of pSrc, yet Slug transcription is unaffected due to reactivation that is mediated through other unknown mechanisms. This results in continued repression of E-cadherin transcription by Slug in resistant cell lines.