Table 2. Interrelationship between clinicopathological variables.

Variables	gender	T	N	M	histology	lya	va	nea	plxa	margin	chemotherapy	CD3	CD4	CD8	FOXP3	FOXP3/CD4
Age (≥60 years/ < 60 years)	NS	NS	0.038	NS	NS	0.005	NS	0.007	0.011	NS	NS	NS	NS	NS	NS	NS
Gender (male/ female)		NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Pathologic tumor status (T1+T2/ T3)			<0.0001	NS	NS	0.008	NS	<0.0001	<0.0001	0.010	NS	NS	NS	NS	NS	NS
Pathologic node status (N0/ N1)				<0.0001	0.010	<0.0001	0.0002	0.010	0.001	<0.0001	NS	NS	NS	NS	NS	NS
Pathologic metastasis status (M0/ M1)					NS	NS	NS	NS	NS	0.012	NS	NS	NS	NS	NS	NS
Histological grade (G1/ G2, G3)						NS	0.001	NS	NS	NS	NS	NS	NS	NS	NS	NS
Lymphatic invasion (0, 1/ 2, 3)a							<0.0001	0.003	0.019	0.001	NS	NS	NS	NS	NS	NS
Venous invasion (0, 1/ 2, 3)a								0.0002	0.0006	0.003	NS	NS	NS	NS	NS	NS
Intrapancreatic neural invasion (0, 1/ 2, 3)a									<0.0001	<0.0001	NS	NS	NS	NS	NS	NS
Nerve plexus invasion (absence/ presence)a										<0.0001	NS	NS	NS	NS	NS	NS
Pathological margin status (negative/ positive)											NS	NS	NS	NS	NS	NS
Adjuvant chemotherapy (positive/ negative)												NS	NS	NS	NS	NS
Expression of CD3 (low/ high)													<0.0001	<0.0001	<0.0001	NS
Expression of CD4 (low/ high)														<0.0001	<0.0001	NS
Expression of CD8 (low/ high)															<0.0001	NS
Expression of FOXP3 (low/ high)																<0.0001
Ratio of FOXP3/CD4 (low/ high)

^aClassified according to the classification of pancreatic carcinoma of Japan Pancreas Societ.

NS: not significantly correlated (P > 0.05), T: pathologic tumor status, N: pathologic node status, M: pathologica metastasis status, histology: histological grade, ly: lymphatic invasion, v: venous invasion, ne: intrapancreatic neural invasion, plx: nervve plexus invasion, margin: pathological margin status, chemotherapy: adjuvant chemotherapy, CD3: expression of CD3 CD4: expression of CD4, CD8: expression of CD8, FOXP3: expression of FOXP3, FOXP3/CD4: ratio of FOXP3/CD4.