Table 3.
Relation of postmortem neuropathologic markers to trajectories of episodic memory and perceptual speed
| Fixed effects | Episodic Memory Estimate (95% CI) |
Perceptual Speed Estimate (95% CI) |
|---|---|---|
| Mean | ||
| Intercept | 0.298 (0.240, 0.355) | 0.163 ((0.070, 0.257) |
| Initial slope | 0.181, (0.147, 0.217) | 0.151 (0.115, 0.192) |
| Change point | 1.446 (1.269, 1.622) | 1.326 (1.095, 1.550) |
| Slope after change point | −0.086 (−0.103, −0.068) | −0.131 (−0.147, −0.115) |
| Amyloid (square root) | ||
| Intercept | 0.006 (−0.026, 0.038) | 0.002 (−0.050, 0.055) |
| Initial slope | 0.000 (−0.017, 0.018) | −0.000 (−0.018, 0.018) |
| Change point | −0.003 (−0.019, 0.014) | −0.003 (−0.012, 0.030) |
| Slope after change point | −0.010 (−0.012, −0.008) | −0.010 (−0.005, −0.001) |
| Tangles | ||
| Intercept | −0.016(−0.023, −0.009) | −0.006 (−0.017, 0.005) |
| Initial slope | 0.004 (−0.000, 0.009) | 0.000 (−0.003, 0.004) |
| Change point | −0.003 (−0.019, 0.014) | −0.003(−0.012, 0.030) |
| Slope after change point | −0.010(−0.012, −0.008) | −0.010 (−0.005, −0.001) |
| Lewy Bodies | ||
| Intercept | −0.058 (−0.143, 0.026) | 0.057 (−0.079, 0.195) |
| Initial slope | 0.016 (−0.030, 0.070) | 0.030 (−0.020, 0.088) |
| Change point | 0.065 (−0.287, 0.147) | 0.098 (−0.344, 0.178) |
| Slope after change point | −0.043 (−0.068, −0.018) | −0.048 (−0.071, −0.026) |
| TDP-43 pathology | ||
| Intercept | −0.002 (−0.037, 0.033) | −0.014 (−0.071, 0.045) |
| Initial slope | −0.007, (−0.026, 0.014) | 0.151 (0.115, 0.192) |
| Change point | 0.058 (−0.041, 0.154) | −0.010 (−0.106, 0.126) |
| Slope after change point | −0.022 (−0.033, −0.012) | −0.016 (−0.025, −0.006) |
| Hippocampal sclerosis | ||
| Intercept | −0.055 (−0.195, 0.086) | −0.059 ((−0.281, 0.166) |
| Initial slope | 0.054, (−0.026, 0.143) | −0.007 (−0.076, 0.078) |
| Change point | 1.446 (1.269, 1.622) | 0.339 (−1.188, 0.815) |
| Slope after change point | −0.086 (−0.103, −0.068) | −0.021 (−0.059, 0.017) |
Note. From 2 mixed-effects change point models adjusted for age, sex, education and duration of follow-up. CI, credible interval.