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. 2019 Feb 19;12(2):e002413. doi: 10.1161/CIRCGEN.118.002413

Figure 2.

Figure 2.

Anti-IL (interleukin)-6R prevents Ang II (angiotensin II)–induced hypertension but does not protect against aortic rupture induced by Ang II and anti-TGF (transforming growth factor)-β infusion. Mice were treated with anti-IL-6R or isotype control (n=22 mice/group) starting one week before Ang II and anti-TGF-β infusion. A, Plasma concentration of cytokines at day 0 (before Ang II and anti-TGF-β infusion) and day 7 to 14. *P<0.05 isotype vs anti-IL-6R; **P<0.01 isotype vs anti-IL-6R; 2-way ANOVA followed by uncorrected Fisher test. B, Plasma concentration of serum amyloid A (SAA) at day 0 (before Ang II and anti-TGF-β infusion) and day 7 to 14. ***P<0.05 isotype vs anti-IL-6R; 2-way ANOVA followed by uncorrected Fisher test. C, Systolic blood pressure measurement using tail cuff at day 0 and 7 after Ang II and anti-TGF-β infusion. ***P<0.001 isotype vs anti-IL-6R; 2-way ANOVA followed by uncorrected Fisher test. D, Survival curves of mice after Ang II and anti-TGF-β infusion. All data for the generation of the graphs shown in Figure 2 were generated in 2 independent experiments and then pooled together.