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. 2019 Feb 19;12(2):e002413. doi: 10.1161/CIRCGEN.118.002413

Figure 3.

Figure 3.

Selective blockage of the IL (interleukin)-6 trans-signaling pathway using sgp130 in the Ang II (angiotensin II) + anti-TGF (transforming growth factor)-β model reduces aortic rupture. Mice were treated with sgp130Fc or human IgG1-Fc (Hum-Fc; n=10 mice/group) starting one week before Ang II and anti-TGF-β infusion. A, Plasma concentration of cytokines at day 0 (before Ang II and anti-TGF-β infusion) and day 7. *P<0.05 Hum-Fc vs sgp130; ***P<0.001 Hum-Fc vs sgp130; 2-way ANOVA followed by uncorrected Fisher test. B, Plasma concentration of serum amyloid A (SAA) at day 0 (before Ang II and anti-TGF-β infusion) and day 7. C, Systolic blood pressure measurement using tail cuff at day 0 and day 7 after Ang II and anti-TGF-β infusion. D, Survival curves of mice after Ang II and anti-TGF-β infusion. *P<0.05 Hum-Fc vs sgp130; Gehan-Breslow-Wilcoxon test. All data for the generation of the graphs shown in Figure 3 were generated in one independent experiment.