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. Author manuscript; available in PMC: 2019 Feb 21.
Published in final edited form as: Annu Rev Nutr. 2017 Jul 17;37:395–422. doi: 10.1146/annurev-nutr-071816-064717

Table 2.

Example Nutrigenomics Studies Leveraging a Nutritional Intervention.

Authors (Year) PMID Diet and Contrast N Study Design Outcome
Konstantinidou (2016) 20179144 Traditional Mediterranean Diet (TMD) with virgin olive oil versus TMD with washed virgin olive oil versus Habitual Diet 90 Randomized Control Trial TMD with olive oil resulted in down regulation of pro-atherogenic genes INFγ, IL7R, ADRB2, POLK
Pu (2015)
(COMIT study)		 26806592 Canola oil
High oleic canola oil
High oleic canola oil enriched with DHA
Flax/safflower oil
Corn/safflower oil		 170 Cross-over randomized control trial ‘A’ allele carriers at snp rs324420 in FAAH gene had significantly higher DHEA levels than CC genotype carriers, indicating a possible beneficial effect on circulating fatty acid levels.
Frankwich (2015) 25769412 ‘Nutrigenetic’ guided diet: four types – balanced, low-fat, low-carbohydrate, and Mediterranean
Standard versus non-guided balanced diet		 51 Randomized Control Trial Participants with low-risk obesity polymorphisms lost significantly more weight.
Wojczynski (2015) 26256467 High fat diet with 83% fat, 14% carbohydrate and 3% protein 872 Genome Wide Association Study 2 snps identified as significant near the APOA1/C3/A4/A5 gene cluster in lipid metabolism
Shab-Bisdar (2015) 26346470 Vit D fortified yogurt drink
Plain yogurt drink		 60 Randomized Control Trial Carriers of the AA genotype of VDR-Cdx-2 had significant decreases in obesity indices compared with carriers of GA and GG genotypes.
Goni (2014) 25870980 Personalized nutrition diet based on genotype.
Diets similar regarding total amount of protein, carbohydrate and vegetables,		 167 Longitudinal cohort Carriers of variant alleles in FTO, MC4R and MTNR1B had lower weight loss than non-carriers.
Women carriers of variant in MTNR1B, who ate high total protein and high animal protein diets loss less weight than wildtype carriers
Renda (2012) 22170367 Caffeine consumption 110 Observational cohort study Variants in the ADORA2A and ADRA2B genes associated with increased blood pressure after caffeine consumption.