Table 1.

Location and Average in silico Scores of all Case-Derived KCNQ1 Variants Based on Three Categories of Rarity

	Ultra-Rare	Rare	Common	Total	Average in silico Score	Range of in silico Scores
N-Terminal Variants	8 (5%)	4 (7%)	2 (7%)	14	4.07±2.33	1 - 8
Transmembrane Variants	96 (61%)	30 (52%)	9 (31%)	135	6.13±1.43	0 - 8
C-Terminal Variants	53 (34%)	24 (41%)	18 (62%)	95	4.92±2.43	0 - 8
Total	157	58	29	244
Average in silico Score	6.05±1.61	5.41±2.07	3.00±2.25
Range of in silico Scores	0 - 8	0 - 8	0 - 7