Table 2. Toxicity profile.

	Grade 1-2				Grade 3-4
	TaxAC %	TC %	OR	p	TaxAC %	TC %	OR	p
Neutropenia	5.69	5.02		0.41	28.24	28.98		0.48
Anemia	28.56	23.42	1.3	0.001	1.34	0.87		0.12
Thrombocytopenia	5.63	3.14	1.8	0.001	1.84	0.29	6.4	<0.001
Leucopenia	1.82	2.73		0.14	24.31	21.12	1.2	0.002
Febrile Neutropenia	0.06	0.20		0.32	4.64	5.84	0.74	0.005
Nausea	21.77	14.25	1.7	<0.001	3.10	1.19	2.6	<0.001
Vomiting	10.37	4.41	2.5	<0.001	1.96	0.89	2.2	<0.001
Diarrhea	13.22	9.03	1.5	<0.001	2.87	2.78		0.8
Mucositis	7.32	5.02	1.6	0.003	2.44	0.89	2.8	<0.001
Constipation	4.20	5.28		0.16	0.33	0.13		0.25
Allergy	3.45	4.75		0.07	0.67	1.90	0.35	<0.001
Rash	3.73	10.44	0.33	<0.001	0.67	1.61	0.4	0.002
Skin toxicity	2.64	3.88	0.67	0.058	0.13	0.66	0.2	0.02
Hand/Foot syndrome	0.67	1.33		0.7	1.23	0.66	1.9	0.013
Nail toxicity	3.12	3.94		0.2	0.06	0.13		0.5
Conjuctivitis	0.81	0.87		0.86	0	0	n/a	n/a
Edema	3.93	4.55		0.4	0.27	0.33		0.7
Fatigue	27.61	24.02	1.2	0.026	5.26	3.17	1.7	<0.001
Neurotoxicity	5.08	5.08		0.99	2.67	1.53	1.8	0.001
Infection	5.92	3.50	1.7	0.006	4.27	4.22		0.9
Arthralgia/myalgia	10.27	16.23	0.59	<0.001	2.85	2.47		0.3
Pain	11.75	12.56		0.5	3.96	3.03	1.3	0.04
Cardiotoxicity	0.88	1.07		0.6	0.75	0.33	2.28	0.015

Abbreviations: OR = odds ratio, TC = taxane & cyclophosphamide, TaxAC = taxane & cyclophosphamide & anthracycline.