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. 2018 Nov 22;25(3):490–497. doi: 10.1093/ibd/izy349

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© 2018 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 1. — Results from univariate analysis of oxylipin and eCB mean mucosal concentrations. A, B, Volcano plots of changes in mean mucosal concentrations of oxylipins and eCBs in treatment-naïve patients vs healthy controls (HCs), and UC deep remission patients vs HCs, respectively. The vertical lines correspond to 2.0-fold up- and downregulation, and the horizontal lines represent a P value of 0.05 (Mann-Whitney U test) at a cutoff FDR value of 0.1. The points in the plots represent metabolite mean concentrations. Metabolites in pink have passed the volcano plot filtering. C, D, Box plots of the autoscaled concentration of DHEA and 12-HETE, respectively. The mean concentrations of these metabolites were found to have significantly changed among the study groups according to Kruskal-Wallis analysis of variance.