Table 2. Overview of parameters in the final model, with estimated value, uncertainty, inter-individual variability, and shrinkage.
| Parameters | (unit) | Parameter Description | Estimates (RSE%) | Variability in CV% (RSE%)c [SHR%] | |||
|---|---|---|---|---|---|---|---|
| Vmax | (EU/h) | Maximum ETX elimination capacity | 442000 | (1) | - | ||
| KM | (EU/L) | Concentration of ETX for half of Vmax | 12600 | (17) | 120 | (21) | [13] |
| Vc | (L) | Volume of distribution for ETX | 36.1 | (20) | 75.3 | (25) | [24] |
| BASEETX | (EU/L) | Baseline ETX (Endochrome, study C+E)b | 155 | (20) | 96.3 | (21) | [18] |
| Baseline ETX (Coatest, study F)b | 1810 | (38) | |||||
| MIX a | (-) | Proportion of individuals with contamination | 0.399 | (20) | - | ||
| Propcont | (-) | Proportionality: BASEETX to contamination | 132 | (15) | - | ||
| MTTTNF-α | (h) | Mean transit time for TNF-α in plasma | 1.04 | (13) | 81.5 | (28) | [14] |
| S0,TNF-α | (ng/L) | Baseline TNF-α (DuoSet, study A+B)b | 281 | (9) | 54.1 | (23) | [13] |
| Baseline TNF-α (DuoSet, study E)b | 25.4 | (12) | |||||
| Baseline TNF-α (BioSource, study C+F)b | 3.06 | (29) | |||||
| Baseline TNF-α (BioSource, study D)b | 68.2 | (15) | |||||
| Emax | (-) | Maximum increase of TNF-α production rate | 2540 | (9) | - | ||
| EC0 | (EU/L) | Concentration of ETX at half of Emax,TNF-α | 286 | (5) | - | ||
| γ | (-) | Sigmoidicity coefficient for Emax relationship | 2.10 | (26) | - | ||
| MTTEC50 | (h) | Mean transit time for EC50EC50,TNF-α | 6.33 | (5) | - | ||
| Tmax | (-) | Maximum increase of EC0,TNF-α | 45100 | (2) | - | ||
| TC50 | (EU/L) | Concentration of ETX at half of Tmax | 29300 | (3) | - | ||
| MTTIL-6 | (h) | Mean transit time for IL-6 in plasma | 1.45 | (11) | 47.4 | (41) | [21] |
| S0,IL-6 | (ng/L) | Baseline IL-6 (DuoSet, study A+B+E)b | 49.2 | (13) | 79.9 | (10) | [6] |
| Baseline IL-6 (BioSource, study C+D+F)b | 8.19 | (10) | |||||
| ESLP,TNF-α | (-) | Slope for TNF-α increase of Rprod,IL-6 | 0.961 | (9) | - | ||
| ESLP,ETX | (-) | Slope for ETX increase of Rprod,IL-6 | 0.00937 | (28) | - | ||
| σ ETX | (%) | Proportional error for ETX | 32.1 | (16) | [23] | ||
| σ TNF-α | (%) | Proportional error for TNF-α | 48.5 | (8) | [11] | ||
| σ IL-6 | (%) | Proportional error for IL-6 | 50.5 | (8) | [11] | ||
Abbreviations: CV%: coefficient of variation; ETX: endotoxin; EU: endotoxin units; IL-6: interleukin-6; RSE%: relative standard error in percent; SHR%: shrinkage in percent; TNF-α: tumor necrosis factor alpha
a parameter was fixed in final estimation, and the RSE% is from the final run of the ETX modelling
b The letters (A-F) refer to the study as designated in Table 1.
c Reported on the approximate standard deviation scale (standard error/variance estimate)/2.