Fig 8. Upregulation of genes involved in phagocytosis in the absence of Dmxl2 in testes from seven-week-old animals.

(A) The top-ranking functional networks according to IPA. Thirty of the 161 genes upregulated in Dmxl2 dcKO testes (molecules in red) are involved in ERK1/2 pathway regulation. The TAM receptor (TYRO3) and ligands (GAS6 and PROS1) are boxed. (B, C) RT-qPCR analyses of the expression of the three TAM receptors (Tyro3, Axl, Mertk) (B) and their ligands (Gas6, Pros1) (C) in the testes of mice of the four different genotypes (Control: Dmxl2^loxP/loxP; Sertoli cell cKO: Dmxl2^loxP/loxP; Amh-Cre; Germ cell cKO: Dmxl2^loxP/-; Vasa-Cre; dcKO: Dmxl2^loxP/-; Vasa-Cre; Amh-Cre). Different letters indicate significant differences between genotypes (pValue<0.05).