Table 2.

CREST-H exclusion criteria

1. Unable to undergo MRI (e.g. non-compatible metal in body, pacemaker)

2. Known allergy to gadolinium contrast dye

3. Creatinine ≥2.5 mg/dl or GFR < 30 cc/min

4. Contralateral ICA stenosis >70% by MRA, CTA or Doppler ultrasound

5. Pre-existing diagnosis of dementia

6. History of severe head trauma defined by loss of consciousness >30 min, or seizure

7. Major depression

8. Education less than 8 years

ICA: internal carotid artery; MRA: magnetic resonance angiography; CTA: computerized tomographic angiograpy