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. 2019 Feb 4;5(1):e307. doi: 10.1212/NXG.0000000000000307

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Pedigree of large multigenerational Indian family exhibiting genotype of the affected and unaffected individuals studied using whole-genome SNP microarray analysis and FISH (“+” identifies the presence of duplication and “-” identifies wild-type allele). (B) Chromosome 15q24.3-q25.1 duplicated region highlighted with red circle encompassing LINGO1 gene. (C) FISH confirming presence of the duplication on chromosome 15 in affected individuals showing enhanced signal for the derivative chromosome (circled to right of figure). FISH = fluorescent in situ hybridization.