FIG 7.

Total cleaved secondary site DNA from the ROO filament and Binary mechanisms with the same and different assembly rate constants. (A) Solid lines simulate cleavage on phage DNA, and dotted lines simulate cleavage of sites on host DNA due to activation by phage DNA. Light blue, total cleavage sites from Binary mechanism; orange, total cleaved sites from ROO filament mechanism. Equations, rate constants, and concentrations are given in Tables S5 to S7. (B) As for panel A, but with rate constants of the Binary mechanism increased 4.6-fold to give the same rate of cleavage on the phage DNA as the ROO filament mechanism. More cleavage of host DNA occurs with the Binary model (compare light blue dotted line to orange dotted line).