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. 2019 Feb 19;93(5):e01728-18. doi: 10.1128/JVI.01728-18

FIG 3.

FIG 3

HIV infection significantly influences Gata-3, T-bet, and RORγt expression. (A to C) Percentages of memory (CD45RA−) CD4 T cells isolated from individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 29), or HIV/PTB (n = 8) expressing Gata-3 (A), RORγt (B), or T-bethigh (C). (D) Correlation between the percentage of memory CD4 T cells expressing T-bethigh and the percentage of memory CD4 T cells expressing Gata-3 in individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 26), or HIV/PTB (n = 8). (E) Correlation between the percentage of IFN-γ-producing M. tuberculosis-specific CD4 T cells and the percentage of memory CD4 T cells expressing T-bethigh of individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 29), or HIV/PTB (n = 8). (F) Correlation between the percentage of IL-4/5/13-producing M. tuberculosis-specific CD4 T cells and the percentage of memory CD4 T cells expressing Gata-3 of TB patients from individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 29), or HIV/PTB (n = 8). (G) Correlation between the levels of IL-17A/F detected in M. tuberculosis-stimulated culture supernatants and the percentage of memory CD4 T cells expressing RORγt individuals of individuals with LTBI (n = 9), HIV/LTBI (n = 6), PTB (n = 26), or HIV/PTB (n = 8). (H) Correlation between the percentage of memory CD4 T cells expressing Gata-3 and the percentage of M. tuberculosis-specific CD4 T cells producing IFN-γ in individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 26), or HIV/PTB (n = 8). (I) Correlation between the percentage of T-bethigh and the percentage of M. tuberculosis-specific CD4 T cells producing IL-4/5/13 in individuals with LTBI (n = 14), HIV/LTBI (n = 12), PTB (n = 26), or HIV/PTB (n = 8). Statistical significance (*; P < 0.05) was calculated using one way Anova (Kruskal-Wallis test) followed by a Mann-Whitney test (A to C) or Spearman rank test for correlations (D to I). NS, not significant.