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. Author manuscript; available in PMC: 2019 Jun 10.
Published in final edited form as: Nat Microbiol. 2018 Dec 10;4(3):396–403. doi: 10.1038/s41564-018-0307-3

Fig. 3. Fecal Bacteroides relative abundance inversely correlates with functional connectivity between left DLPFC and DMN structures in patients with Major Depressive Disorder (MDD).

Fig. 3.

(A) 3-Dimensional plots of the medial surface of the left and right hemispheres in patients with MDD (n=23). Significant cluster of 387 voxels in which fecal Bacteroides relative abundance correlated inversely with functional connectivity between this cluster and the left DLPFC. Colorbar shows Z scores of beta weights of the Bacteroides relative abundance covariate of a multiple linear regression with functional connectivity as the dependent variable. (B) Scatter plot of the average functional connectivity (Z score) over a sphere of radius 5mm centered at the voxel of peak significance (+12, −57, 0 in MNI coordinates) and abundance of fecal Bacteroides (Pearson r = −0.67, p=.0005). n=23.