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A) Schematic for i.LN injection of MOG/Rapa MPs and analysis of their tolerogenic effects. B) Encapsulation of both MOG and rapamycin is required for the most potent tolerance. C) Tolerance induced by MOG/Rapa MPs is antigen specific. D) MOG/Rapa increases TREG in treated and untreated LNs. E) MOG/Rapa MPs reduce T cell proliferation in the CNS of mice induced with EAE. Adapted from [100].
