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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Health Phys. 2019 Apr;116(4):484–502. doi: 10.1097/HP.0000000000000961

Figure 2. Basal differences in plasma metabolites between naïve female and male C57BL/6 mice.

Figure 2.

(a) PLS-DA plot: basal female (red) v male (green); n=5 per group; R2=1.0, Q2=0.96. Each point represents a data set from an individual animal. The 95% confidence intervals are indicated by elliptical patterns per group. Data were sum normalized, log transformed, and mean centered. (b) Volcano Plot: basal female v male; n=5 per group. FC=fold change, p=pvalue. Red dots are metabolites with p<0.001, blue dots are metabolites with p<0.01, and orange dots are metabolites with p<0.05. (c) Class distribution of significantly changed metabolites listed in Supplemental Table 2 (p<0.05). (d-f) PC_34–3, PC_O-38–3, and SM_42-1 as representative metabolites that are significantly different between female and male cohorts. All plasma metabolites assayed from 3 month old C57BL/6 mice; n=10 for each female and male grouped cohort (Naïve, IR) where each n=10 cohort had n=5 each of female and male. Mean ± SD; *p<0.05. M=male, F=female, IR=3 d post-8.72 Gy, naïve = sham.