Table 2. Plasma metabolites assayed at 3 days post-8.72 Gy TBI: female single-sex cohort.
Metabolites assayed from 3 mo. old C57BL/6 mice; n=5 for each cohort (Naïve, IR). p < 0.05 between female cohorts of naïve and IR.
| Female_Naive | Female_TBI | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite | mean | SD | SEM | %CV | N | mean | SD | SEM | %CV | N | P value Naïve vs. TBI |
Differential Expression (up) |
* FDR< 5% |
** also changed when grouped with male |
Class | |||||||||||||||||||
| 1 | LPC_20-3 | 4.22 | 0.53 | 0.24 | 12.50 | 5 | 2.91 | 0.36 | 0.16 | 12.51 | 5 | 0.0018 | Female_Naive | ** | LPC | |||||||||||||||||||
| 2 | Cit | 77.36 | 17.77 | 7.95 | 22.97 | 5 | 38.84 | 10.27 | 4.59 | 26.45 | 5 | 0.0030 | Female_Naive | ** | AA | |||||||||||||||||||
| 3 | Cit / Orn | 1.44 | 0.32 | 0.14 | 21.97 | 5 | 0.70 | 0.28 | 0.13 | 40.48 | 5 | 0.0046 | Female_Naive | ** | AA | |||||||||||||||||||
| 4 | LPC_28-1 | 0.15 | 0.01 | 0.01 | 8.48 | 5 | 0.18 | 0.01 | 0.00 | 3.06 | 5 | 0.0056 | Female_TBI | F only | LPC | |||||||||||||||||||
| 5 | PC_26-0 | 0.65 | 0.07 | 0.03 | 11.49 | 5 | 0.80 | 0.05 | 0.02 | 6.47 | 5 | 0.0060 | Female_TBI | F only | PC | |||||||||||||||||||
| 6 | SM_34-2 | 2.15 | 0.18 | 0.08 | 8.24 | 5 | 2.60 | 0.21 | 0.09 | 7.91 | 5 | 0.0065 | Female_TBI | F only | SM | |||||||||||||||||||
| 7 | Total SM-OH / Total SM-non OH | 0.14 | 0.01 | 0.00 | 5.73 | 5 | 0.12 | 0.01 | 0.00 | 4.71 | 5 | 0.0079 | Female_Naive | F only | SM | |||||||||||||||||||
| 8 | MUFA_PC / SFA_PC | 4.96 | 0.48 | 0.22 | 9.78 | 5 | 4.06 | 0.31 | 0.14 | 7.56 | 5 | 0.0084 | Female_Naive | ** | PC | |||||||||||||||||||
| 9 | SM_34-1 | 15.96 | 1.75 | 0.78 | 10.96 | 5 | 19.47 | 1.72 | 0.77 | 8.84 | 5 | 0.0126 | Female_TBI | ** | SM | |||||||||||||||||||
| 10 | SM_36-2 | 0.77 | 0.10 | 0.04 | 12.92 | 5 | 0.95 | 0.08 | 0.04 | 8.83 | 5 | 0.0143 | Female_TBI | ** | SM | |||||||||||||||||||
| 11 | Cit / Arg | 0.73 | 0.17 | 0.07 | 22.86 | 5 | 0.42 | 0.15 | 0.07 | 36.74 | 5 | 0.0154 | Female_Naive | ** | AA | |||||||||||||||||||
| 12 | Orn / Arg | 0.51 | 0.05 | 0.02 | 10.34 | 5 | 0.60 | 0.04 | 0.02 | 7.31 | 5 | 0.0167 | Female_TBI | F only | AA | |||||||||||||||||||
| 13 | PC_38-6 | 81.05 | 8.55 | 3.82 | 10.55 | 5 | 96.84 | 8.22 | 3.67 | 8.48 | 5 | 0.0177 | Female_TBI | F only | PC | |||||||||||||||||||
| 14 | PC_O-44-3 | 0.12 | 0.01 | 0.00 | 5.64 | 5 | 0.13 | 0.01 | 0.00 | 5.63 | 5 | 0.0197 | Female_TBI | F only | PC | |||||||||||||||||||
| 15 | LPC_26-0 | 0.17 | 0.01 | 0.00 | 3.05 | 5 | 0.22 | 0.04 | 0.02 | 15.98 | 5 | 0.0204 | Female_TBI | F only | LPC | |||||||||||||||||||
| 16 | PC_O-38-0 | 1.65 | 0.18 | 0.08 | 10.97 | 5 | 1.96 | 0.16 | 0.07 | 8.11 | 5 | 0.0215 | Female_TBI | F only | PC | |||||||||||||||||||
| 17 | Spermidine | 1.05 | 0.24 | 0.11 | 22.78 | 5 | 0.65 | 0.22 | 0.10 | 33.31 | 5 | 0.0243 | Female_Naive | ** | BA | |||||||||||||||||||
| 18 | PC_38-3 | 17.46 | 3.08 | 1.38 | 17.65 | 5 | 13.62 | 0.86 | 0.39 | 6.33 | 5 | 0.0278 | Female_Naive | F only | PC | |||||||||||||||||||
| 19 | C2 | 16.01 | 1.50 | 0.67 | 9.39 | 5 | 13.14 | 1.88 | 0.84 | 14.28 | 5 | 0.0282 | Female_Naive | ** | AC | |||||||||||||||||||
| 20 | PC_34-3 | 9.33 | 1.08 | 0.48 | 11.58 | 5 | 11.03 | 0.98 | 0.44 | 8.92 | 5 | 0.0314 | Female_TBI | F only | PC | |||||||||||||||||||
| 21 | total DMA | 0.61 | 0.04 | 0.02 | 7.30 | 5 | 0.53 | 0.05 | 0.02 | 9.75 | 5 | 0.0344 | Female_Naive | ** | BA | |||||||||||||||||||
| 22 | Ac-Orn | 2.38 | 0.34 | 0.15 | 14.18 | 5 | 1.61 | 0.59 | 0.26 | 36.58 | 5 | 0.0357 | Female_Naive | ** | BA | |||||||||||||||||||
| 23 | Spermine / Spermidine | 0.46 | 0.07 | 0.03 | 14.28 | 5 | 0.70 | 0.20 | 0.09 | 29.13 | 5 | 0.0370 | Female_TBI | ** | BA | |||||||||||||||||||
| 24 | LPC_26-1 | 0.08 | 0.01 | 0.01 | 14.52 | 5 | 0.11 | 0.02 | 0.01 | 19.21 | 5 | 0.0467 | Female_TBI | F only | LPC | |||||||||||||||||||
| 25 | alpha-AAA | 11.38 | 4.13 | 1.85 | 36.32 | 5 | 6.59 | 2.03 | 0.91 | 30.78 | 5 | 0.0483 | Female_Naive | ** | BA | |||||||||||||||||||
| 26 | Total SM-non OH | 33.56 | 4.36 | 1.95 | 13.00 | 5 | 39.02 | 3.00 | 1.34 | 7.68 | 5 | 0.0499 | Female_TBI | F only | SM | |||||||||||||||||||