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. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Health Phys. 2019 Apr;116(4):558–565. doi: 10.1097/HP.0000000000000919

Fig. 2 — Fibrosis in nonirradiated and irradiated cardiac tissue. Cardiac fibrosis was assessed by blue color in trichrome stained sections of hearts after 100 days. Representative sections of the left ventricles (a–d) and right ventricles (e–h) are shown separately. Cardiac myocytes are shown from nonirradiated (a,b,e,f) and irradiated (c,d,g,h) hearts as follows: a) left ventricle from nonirrradiated heart; b) left ventricle from lisinopril-treated, nonirrradiated heart; c) left ventricle from irradiated (13 Gy leg-out PBI) heart; d) left ventricle from lisinopril-treated, irradiated heart; e) right ventricle from nonirradiated heart; f) right ventricle from lisinopril-treated, nonirradiated heart; g) right ventricle from irradiated heart; h) right ventricle from lisinopril-treated, irradiated heart. Blue color was quantitated by measuring the ratio of blue:red color separately and presented as means±SD (Fig 2i and 2j). Bars represent nonirradiated and irradiated groups without and with lisinopril as marked. Though interstitial fibrosis was increased in ventricles after irradiation (*p<0.05, n=9 nonirradiated; n=5 nonirradited+lisinopril; n=6 irradiated only; n=4 irradiated+lisinopril) as compared to corresponding nonirradiated ventricles or irradiated ventricles with lisinopril, fibrosis was minimal in rat hearts with or without irradiation or drug, and not expected to contribute significantly to cardiac dysfunction or remodeling.

Fig. 2 — Fibrosis in nonirradiated and irradiated cardiac tissue. Cardiac fibrosis was assessed by blue color in trichrome stained sections of hearts after 100 days. Representative sections of the left ventricles (a–d) and right ventricles (e–h) are shown separately. Cardiac myocytes are shown from nonirradiated (a,b,e,f) and irradiated (c,d,g,h) hearts as follows: a) left ventricle from nonirrradiated heart; b) left ventricle from lisinopril-treated, nonirrradiated heart; c) left ventricle from irradiated (13 Gy leg-out PBI) heart; d) left ventricle from lisinopril-treated, irradiated heart; e) right ventricle from nonirradiated heart; f) right ventricle from lisinopril-treated, nonirradiated heart; g) right ventricle from irradiated heart; h) right ventricle from lisinopril-treated, irradiated heart. Blue color was quantitated by measuring the ratio of blue:red color separately and presented as means±SD (Fig 2i and 2j). Bars represent nonirradiated and irradiated groups without and with lisinopril as marked. Though interstitial fibrosis was increased in ventricles after irradiation (*p<0.05, n=9 nonirradiated; n=5 nonirradited+lisinopril; n=6 irradiated only; n=4 irradiated+lisinopril) as compared to corresponding nonirradiated ventricles or irradiated ventricles with lisinopril, fibrosis was minimal in rat hearts with or without irradiation or drug, and not expected to contribute significantly to cardiac dysfunction or remodeling.