Table 1a.

Summary of echocardiographic and doppler measurements in 4 groups of rats: (nonirradiated (0 Gy), nonirradiated + lisinopril, irradiation only (13 Gy leg-out PBI) and irradiation+lisinopril, at 50 days.

Echocardiogram Parameters	Mean ± SD
Days	50	50	50	50
Groups	0 Gy n=13	0 Gy + Lis n=5	13 Gy only n=12	13 Gy + lis n=13
HR (beats/min)	380±31	397±15	382±51	374±34
SV (ml)	0.48±0.07	0.48±0.05	0.31±0.16+*	0.46±0.06#
RV width (cm)	0.20±0.01		0.25±0.06	0.19±0.03#
LVIDd (cm)&	3.50±0.27	3.63±0.27	3.52±0.87	4.10±0.98
EDV (ml)&	3.22±0.42	3.40±0.46	2.37±1.33	4.02±0.52#
IVSD (cm)&	0.85±0.13	0.82±0.05	1.17±0.36+*	0.84±0.17#
LVPWd (cm)&	0.78±0.13	0.70±0.08	1.10±0.18+*	0.75±0.11#
ESV (ml)&	0.52±0.21	0.63±0.10	0.27±0.23+*	0.84+0.22*,#
LVIDs (cm)&	1.82±0.33	1.99±0.12	1.55±0.56	2.50±0.24*,#
TAPSE	0.20±0.05		0.16±0.04	0.21±0.03
PAT (ms)	25.52±3.56	23.04±3.78	18.8±6.16*	23.01±5.38
ET (ms)	62.32±3.74	61.88±6.05	68.56±6.48	63.66±6.67
PAT/ET	0.41±0.05	0.37±0.03	0.28±0.10*	0.37±0.09
IVRT (ms)	12.72±2.31	10.39±1.89	19.59±7.75+*	13.66±1.68#
RVOT (cm)	2.47±0.45	2.14±0.32	2.31±0.71	2.52±0.44
% EF	83.8±6.4	81.2±2.0	89.9±4.1+*	79.1±4.2#
% FS	48.3±7.8	44.6±1.9	55.7±6.2+*	42.7±4.1#
TR frequency	0/13	0/5	6/12	0/13

HR-heart rate, SV-stroke volume, RV width-right ventricular width, LVIDd-left ventricular internal dimension (diastole), EDV-left end diastolic volume, IVSD-inter ventricular septum diastole, LVPWd-left ventricle posterior wall (diastole), ESV-left end systolic volume, LVIDs-left ventricular internal dimension (systole), TAPSE-tricuspid annular peak systolic excursion, PAT-pulmonary acceleration time, PAT/ET- pulmonary acceleration time/ejection time, ET-ejection time, IVRT-isovolumic relaxation time, RVOT-right ventricular outflow tract, EF-ejection fraction, FS-fractional shortening, TR-tricuspid regurgitation.

^&normalized for body weight (Kg⁻¹);

^*p<0.0083 versus nonirradiated rats at 50 days;

^#p<0.0083 versus irradiation only at 50 days;

⁺p<0.0083 versus nonirradiated with lisinopril rats at 50 days.