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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Am J Transplant. 2018 Sep 17;19(3):646–661. doi: 10.1111/ajt.15083

Figure 6.

Figure 6

MHC-mismatched skin grafts from TORC2DC−/− B6 donors elicit enhanced numbers of CD8+ and CD8+PD-1+ T cells in draining lymph nodes (LN) of WT BALB/c recipients. T cells were isolated from the axillary LN of graft recipients on post-operative day 5. (A) Numbers of CD4+CD25-Foxp3- T effector (Teff) cells, CD8+ T cells and the ratio of Teff: Treg (CD4+CD25+Foxp3+) cells. (B) Representative histograms of CD8+PD-1+ T cells within LN of each group. (C) Numbers of CD8+PD-1+ T cells within LN (left) and MFI of PD-1 on PD-1+ cells (right). n=4 mice per group; one-way ANOVA Tukey’s multiple comparisons test, *, p < 0.05; **, p<0.01, ***, p<0.001.