Table 1.
Tetrabenazine | Risperidone | P‐value | |
---|---|---|---|
N | 72 | 72 | |
% Female | 63.6 | 50.0 | 53.1 |
CAG, mean ± S.D. | 44.26 ± 3.24 | 43.79 ± 3.18 | 0.379 |
Age0 (yrs), mean ± S.D. | 53.77 ± 11.55 | 54.01 ± 11.85 | 0.904 |
AMO (yrs), mean ± S.D. | 44.42 ± 10.63 | 46.72 ± 10.55 | 0.199 |
CAP0, mean ± S.D. | 117.60 ± 14.82 | 114.47 ± 17.40 | 0.247 |
TMS0, mean ± S.D. | 40.81 ± 17.70 | 39.56 ± 17.89 | 0.674 |
TFC0, mean ± S.D. | 7.10 ± 3.20 | 7.24 ± 3.14 | 0.793 |
Weight0 (kg), mean ± S.D. | 73.03 ± 15.80 | 77.50 ± 17.33 | 0.108 |
BMI0 (kg/m2), mean ± S.D. | 25.57 ± 4.86 | 26.45 ± 4.79 | 0.272 |
Baseline depression score, mean ± S.D. | 1.39 ± 2.53 | 3.09 ± 3.94 | 0.003 |
Baseline suicidality score, mean ± S.D. | 0.07 ± 0.35 | 0.24 ± 0.75 | 0.082 |
Baseline aggression score, mean ± S.D. | 0.83 ± 1.99 | 1.01 ± 2.16 | 0.603 |
Baseline irritability score, mean ± S.D. | 1.99 ± 2.85 | 2.73 ± 3.70 | 0.178 |
Time between first and second visit (yrs), mean ± S.D. | 1.09 ± 0.22 | 1.07 ± 0.25 | 0.641 |
Daily dose (mg), mean ± S.D.1 | 56.53 ± 41.17 | 1.76 ± 1.60 | N/A |
Prior time on therapy (yrs), mean ± S.D. | 1.80 ± 2.05 | 2.39 ± 2.49 | 0.125 |
Medication indicated for chorea, %1 | 100 | 55.6 | N/A |
Abbreviations: AMO, Age of motor onset; BMI0, Baseline body mass index; CAG, Cytosine‐Adenine‐Guanine; CAP0, Baseline disease burden score calculated (age0 x [CAG‐30]/6.27); TFC0, Baseline Total Functional Capacity score; TMS0, Baseline total motor score.
Statistical significance not calculated