Table 3.
Tetrabenazine | Olanzapine | P‐value | |
---|---|---|---|
N | 77 | 77 | |
% Female | 50.0 | 50.0 | 1.000 |
CAG, mean±S.D. | 43.14 ± 2.87 | 43.48 ± 2.85 | 0.466 |
Age0 (yrs), mean±S.D. | 57.91 ± 10.57 | 56.30 ± 11.00 | 0.355 |
AMO (yrs), mean±S.D. | 48.03 ± 10.70 | 47.47 ± 10.83 | 0.752 |
CAP0, mean±S.D. | 117.86 ± 17.80 | 117.45 ± 17.51 | 0.884 |
TMS0, mean±S.D. | 43.75 ± 18.02 | 42.78 ± 19.04 | 0.745 |
TFC0, mean±S.D. | 7.04 ± 3.09 | 6.96 ± 3.10 | 0.876 |
Weight0 (kg), mean±S.D. | 74.17 ± 16.41 | 72.63 ± 17.35 | 0.573 |
BMI0 (kg/m2), mean±S.D. | 25.64 ± 5.90 | 25.18 ± 5.23 | 0.606 |
Baseline depression score, mean±S.D. | 1.62 ± 2.70 | 2.61 ± 3.50 | 0.052 |
Baseline suicidality score, mean±S.D. | 0.05 ± 0.28 | 0.43 ± 1.52 | 0.035 |
Baseline aggression score, mean±S.D. | 0.62 ± 1.71 | 1.21 ± 2.07 | 0.058 |
Baseline irritability score, mean±S.D. | 1.56 ± 2.63 | 2.70 ± 3.44 | 0.022 |
Time between first and second visit (yrs), mean±S.D. | 1.09 ± 0.27 | 1.06 ± 0.23 | 0.477 |
Daily dose (mg), mean±S.D.1 | 60.07 ± 53.84 | 6.95 ± 5.88 | N/A |
Prior time on therapy (yrs), mean±S.D. | 2.23 ± 2.20 | 2.16 ± 2.55 | 0.840 |
Medication indicated for chorea, %1 | 100 | 41.6 | N/A |
Abbreviations: AMO, age of motor onset; BMI0, baseline body mass index; CAG: cytosine‐adenine‐guanine; CAP0: baseline disease burden score calculated age0 x ([CAG‐30]/6.27); TFC0: baseline total functional capacity score; TMS0: baseline total motor score.
Statistical significance not calculated.